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Clinical characteristics, severity and mortality of adult cancer patients affected by COVID-19
Clinical characteristics, severity and mortality of adult cancer patients affected by COVID-19
Juan A. Serrano-Olvera 1, Luis F. Manríquez Cedillo-de la Borbolla 2, Geovani Amador-García 3, Fernando M. Serrano-Baltazar 4, Alberto Villalobos-Prieto 5, Fabiola Flores-Vázquez 6, Raquel Gerson-Cwilich 3
1 Departamento de Oncología Médica, Centro Médico ABC - Observatorio, Ciudad de México, México; 2 Departamento de Medicina General, Centro Médico ABC, Ciudad de México, México; 3 Departamento de Oncología Médica, Centro Médico ABC, Ciudad de México, México; 4 Carrera Médico Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Edo. de México, México; 5 Departamento de Hemato-Oncología, Centro Médico ABC, Ciudad de México, México; 6 Departamento de Radio-Oncología, Centro Médico ABC, Ciudad de México, México
*Correspondence: Juan A. Serrano-Olvera. Email: serranoolvera@gmail.com
Abstract
Background: Coronavirus Disease 2019 (COVID-19) in cancer patients seems to induce higher severity and mortality.
Objectives: To describe the clinical characteristics, severity and mortality rate in adult cancer patients with COVID-19.
Methods and material: Review of literature from January 1st to May 31st 2020 and combined analysis of individual data.
Results: Twenty-six studies were analyzed, 3,700 cases and 718 deaths (19.4%), the men represented 51.6%. Systemic arterial hypertension was reported in 34.9%, diabetes mellitus 16.6%, and obesity 18%. Breast (23.7%), gastrointestinal (14.4%) and lung cancer (11.5%) predominated; 40.6% had received cancer treatment within 30 days. Frequent symptoms were fever (65.1%), cough (46.8%), dyspnea (40.1%), fatigue (25%), and diarrhea (9.5%). The infection was severe in 27.8% and critical in 11.8%. The 63.3% required hospitalization and 11.3% intensive care. Additionally, 61.1% of them required supplementary oxygen, 17.2% non-invasive ventilation, and 9.1% oro-tracheal intubation. It was not possible to identify factors associated with severity and mortality.
Conclusions: COVID-19 in adults with cancer was severe or critical in 40% of cases; furthermore, 30% requires hospitalization and ventilatory support. The mortality rate was 19.4%.
Keywords: COVID-19. Cancer. Mortality.
