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Pregabalin for the management of postoperative pain in proctological surgeries
Pregabalin for the management of postoperative pain in proctological surgeries
Iván A. Sánchez-Cano 1 
, Carlos A. López-Bernal 2 , Omar Bazán-Ordeñana 3, Álvaro J. Montiel-Jarquín 4 , Irma A. Barranco-Cuevas 5 , Jorge Loría-Castellanos 6 , Nancy R. Bertado-Ramírez 4 , Angélica Porras-Juárez 4 , José A. Parra-Salazar 7 , Arturo García-Galicia 8 , Sandra Maldonado-Castañeda 9
1 Departamento de Cirugía General;Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, México; 2 Departamento de Cirugía General, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, México; 3 Departamento de Anestesiología, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, México; 4 Dirección de Educación e Investigación enSalud, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social, Puebla, Puebla, México; 5 Departamento de Medicina Familiar, Unidad de Medicina Familiar No. 7, Órgano de Operación Administrativa Desconcentrada de Puebla, IMSS. Puebla, Puebla, México; 6 Red Nacional de Educadores en Simulación Clínica, Ciudad de México. México; 7 Dirección General, Hospital de Especialidades Puebla, Centro Médico Nacional General de División Manuel Ávila Camacho, Puebla, Pue., México; 8 Dirección de Educación e Investigación en Salud, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS) Puebla, México; 9 Modelo de Atención a la Salud para el Bienestar, IMSS Bienestar, Puebla, Pue., México
*Correspondence: Álvaro J. Montiel-Jarquín. Email: dralmoja@hotmail.com
Abstract
Background: The management of postoperative pain is a challenge for physicians performing proctological surgeries. The use of non-steroidal anti-inflammatory drugs and opioids is described in the management.
Objective: To compare the efficacy and safety of pregabalin compared to ketorolac for pain management in these patients.
Material and methods: A comparative study conducted in patients who underwent proctological surgery from March 2021 to September 2024. Group A received pregabalin, 75 mg/dose total, and group B received ketorolac, 30 mg/dose. The degree of postoperative pain was measured using the VAS at 2 and 24 hours.
Results: The mean pain values in patients at 2 hours were 4.07 and 4.23 for pregabalin and ketorolac, respectively, without statistically significant difference (p ≥ 0.001), and at 24 hours were 1.92 and 1.90, also showing not statistically significant difference (p ≥ 0.001). There was a decrease in pain in both groups of patients at 24 hours compared to 2 hours post-surgery, with statistically significant differences (p ≤ 0.001).
Conclusions: Pregabalin is effective for managing postoperative pain in proctological surgery; however, it presents side effects that should be considered and managed.
Keywords: Pregabalin. Postoperative pain. Proctological surgery. Effectiveness.
