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Pregabalin for the management of postoperative pain in proctological surgeries
Pregabalin for the management of postoperative pain in proctological surgeries
Iván A. Sánchez-Cano 1 
, Carlos A. López-Bernal 2 , Omar Bazán-Ordeñana 3, Álvaro J. Montiel-Jarquín 4 , Irma A. Barranco-Cuevas 5 , Jorge Loría-Castellanos 6 , Nancy R. Bertado-Ramírez 4 , Angélica Porras-Juárez 4 , José A. Parra-Salazar 7 , Arturo García-Galicia 8 , Sandra Maldonado-Castañeda 9
1 Departamento de Cirugía General;Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, México; 2 Departamento de Cirugía General, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, México; 3 Departamento de Anestesiología, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, México; 4 Health Education and Research Direction, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Pue., México; 5 Departamento de Medicina Familiar, Unidad de Medicina Familiar No. 7, Órgano de Operación Administrativa Desconcentrada de Puebla, IMSS. Puebla, Puebla, México; 6 National Clinical Simulation Network, Mexico City, Mexico; 7 General Management, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Pue., México; 8 Jefatura de División de Investigación en Salud, Centro Médico Nacional General de División Manuel Ávila Camacho, Unidad Médica de Alta Especialidad Hospital de Especialidades de Puebla, IMSS. Puebla de Zaragoza, Puebla, México; 9 Health Care Model for Well-Being, IMSS Bienestar, Puebla, Pue., México
*Correspondence: Álvaro J. Montiel-Jarquín. Email: dralmoja@hotmail.com
Abstract
Background: The management of postoperative pain is a challenge for physicians performing proctological surgeries. The use of non-steroidal anti-inflammatory drugs and opioids is described in the management.
Objective: To compare the efficacy and safety of pregabalin compared to ketorolac for pain management in these patients.
Material and methods: A comparative study conducted in patients who underwent proctological surgery from March 2021 to September 2024. Group A received pregabalin, 75 mg/dose total, and group B received ketorolac, 30 mg/dose. The degree of postoperative pain was measured using the VAS at 2 and 24 hours.
Results: The mean pain values in patients at 2 hours were 4.07 and 4.23 for pregabalin and ketorolac, respectively, without statistically significant difference (p ≥ 0.001), and at 24 hours were 1.92 and 1.90, also showing not statistically significant difference (p ≥ 0.001). There was a decrease in pain in both groups of patients at 24 hours compared to 2 hours post-surgery, with statistically significant differences (p ≤ 0.001).
Conclusions: Pregabalin is effective for managing postoperative pain in proctological surgery; however, it presents side effects that should be considered and managed.
Keywords: Pregabalin. Postoperative pain. Proctological surgery. Effectiveness.
