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Pregabalin for the management of postoperative pain in proctological surgeries
Pregabalin for the management of postoperative pain in proctological surgeries
Iván A. Sánchez-Cano 1 
, Carlos A. López-Bernal 2 , Omar Bazán-Ordeñana 3, Álvaro J. Montiel-Jarquín 4 , Irma A. Barranco-Cuevas 5 , Jorge Loría-Castellanos 6 , Nancy R. Bertado-Ramírez 7 , Angélica Porras-Juárez 8 , José A. Parra-Salazar 9 , Arturo García-Galicia 4 , Sandra Maldonado-Castañeda 10
1 Departamento de Cirugía General;Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, México; 2 Departamento de Cirugía General, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, México; 3 Departamento de Anestesiología, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Puebla, México; 4 Dirección de Educación e Investigación en Salud. Unidad Médica de Alta Especialidad, Hospital de Especialidades de Puebla, Centro Médico Nacional Gral. de Div. Manuel Ávila Camacho, Instituto Mexicano del Seguro Social, Puebla de Zaragoza, Pue., México; 5 Departamento de Medicina Familiar, Unidad de Medicina Familiar No. 7, Órgano de Operación Administrativa Desconcentrada de Puebla, IMSS. Puebla, Puebla, México; 6 Centro de Simulación, Universidad Anáhuac, Ciudad de México. México; 7 Directorate of Health Education and Research, Centro Médico Nacional Gral. de Div. Manuel Ávila Camacho. Puebla, Pue., Mexico; 8 Dirección de Educación e Investigación enSalud, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social, Puebla, Puebla, México; 9 Dirección General, Hospital de Especialidades Puebla, Centro Médico Nacional General de División Manuel Ávila Camacho, Puebla, Pue., México; 10 Modelo de Atención a la Salud para el Bienestar, IMSS Bienestar, Puebla, Pue., México
*Correspondence: Álvaro J. Montiel-Jarquín. Email: dralmoja@hotmail.com
Abstract
Background: The management of postoperative pain is a challenge for physicians performing proctological surgeries. The use of non-steroidal anti-inflammatory drugs and opioids is described in the management.
Objective: To compare the efficacy and safety of pregabalin compared to ketorolac for pain management in these patients.
Material and methods: A comparative study conducted in patients who underwent proctological surgery from March 2021 to September 2024. Group A received pregabalin, 75 mg/dose total, and group B received ketorolac, 30 mg/dose. The degree of postoperative pain was measured using the VAS at 2 and 24 hours.
Results: The mean pain values in patients at 2 hours were 4.07 and 4.23 for pregabalin and ketorolac, respectively, without statistically significant difference (p ≥ 0.001), and at 24 hours were 1.92 and 1.90, also showing not statistically significant difference (p ≥ 0.001). There was a decrease in pain in both groups of patients at 24 hours compared to 2 hours post-surgery, with statistically significant differences (p ≤ 0.001).
Conclusions: Pregabalin is effective for managing postoperative pain in proctological surgery; however, it presents side effects that should be considered and managed.
Keywords: Pregabalin. Postoperative pain. Proctological surgery. Effectiveness.
