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Comparison of sedation with propofol versus propofol-midazolam in endoscopy
Comparison of sedation with propofol versus propofol-midazolam in endoscopy
Nataly Y. Cortés-Trujillo 1, Arturo García-Galicia 2 
, Mauricio I. Gutiérrez-Razo 1 , Oliva S. Ramírez-Castillo 3 , Martha A. Montes-Alvarado 3 , Zaira A. Contreras-Sánchez 2 , Álvaro J. Montiel-Jarquín 4 , Susana Barrera-Hernández 1 , Jorge Loría-Castellanos 5
1 Dirección de Educación e Investigación, Unidad Médica de Alta Especialidad Hospital de Especialidades de Puebla, Centro Médico Nacional General Manuel Ávila Camacho, Instituto Mexicano del Seguro Social, Puebla de Zaragoza, Puebla, México; 2 Jefatura de División de Investigación en Salud, Centro Médico Nacional General de División Manuel Ávila Camacho, Unidad Médica de Alta Especialidad Hospital de Especialidades de Puebla, IMSS. Puebla de Zaragoza, Puebla, México; 3 Servicio de Anestesiología. Unidad Médica de Alta Especialidad Hospital de Especialidades de Puebla, Centro Médico Nacional General Manuel Ávila Camacho, Instituto Mexicano del Seguro Social, Puebla de Zaragoza, Puebla, Mexico; 4 Health Education and Research Direction, Hospital de Especialidades de Puebla, Instituto Mexicano del Seguro Social (IMSS), Puebla, Pue., México; 5 National Clinical Simulation Network, Mexico City, Mexico
*Correspondence: Arturo García-Galicia. Email: neurogarciagalicia@yahoo.com.mx
Abstract
Background: Sedation is essential in gastrointestinal endoscopy, as it improves patient tolerance and facilitates the procedure. Propofol is widely used because of its rapid onset and short duration; however, in some cases it is combined with midazolam, which may affect recovery time. Objective: To compare recovery times from sedation with propofol versus propofol plus midazolam during endoscopic procedures. Material and methods: An observational, comparative, cross-sectional study was conducted in the endoscopy unit of a tertiary hospital of the Mexican Social Security Institute in Puebla, Mexico. The study included 60 patients who underwent endoscopy between May and August 2024. Patients were grouped according to the sedation regimen: propofol or propofol plus midazolam. Recovery was assessed using the Aldrete scale at 5 and 10 minutes. Descriptive statistics and the chi-square test were used. Results: Both protocols yielded similar scores on the Aldrete scale. At the 5-minute mark, a higher proportion of high scores was observed in the combined group, though there were no statistically significant differences. Conclusions: Sedation with propofol and its combination with midazolam result in comparable recovery times, with both options being safe and effective.
Keywords: Sedation. Aldrete scale. Gastrointestinal endoscopy.
