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Gastric carcinoma in a 25-year-old man with Fanconi anemia: case report and literature review
Gastric carcinoma in a 25-year-old man with Fanconi anemia: case report and literature review
Warda A. Romero-Budib 
, Cynthia S. Cruz-Medina 1 , Víctor M. Vargas-Vargas 2 , Idalia Hernández- Coronel 1 , Armando Basilio-Roque 1 , Arturo García-Galicia 3 , Jorge Loría-Castellanos 4 , Eduardo Téllez-Bernal 5 , Salvador Macías-Díaz 5 , Miriam I. Escamilla López 5
1 Oncology Unit, IMSS Bienestar Puebla, Mexico; 2 Care Division, Secretaría de Salud del Estado de Puebla, Puebla, Mexico; 3 Jefatura de División de Investigación en Salud, Centro Médico Nacional General de División Manuel Ávila Camacho, Unidad Médica de Alta Especialidad Hospital de Especialidades de Puebla, IMSS. Puebla de Zaragoza, Puebla, México; 4 National Clinical Simulation Network, Mexico City, Mexico; 5 Department of Medical Oncology, Unidad Médica Onco-Hematológica, Puebla, Pue. Mexico
*Correspondence: Cynthia S. Cruz-Medina. Email: ed_hope@hotmail.com
Abstract
Fanconi anemia (FA) is a rare genetic disorder characterized by defective DNA repair, genomic instability, and bone marrow failure. It affects approximately 1 in 200,000 live births and increases the risk of malignancies, including solid tumors. We report a 25-year-old man with FA who presented severe weight loss, vomiting, and oral intolerance. Imaging revealed pyloric stenosis and gastric wall thickening. Endoscopy confirmed intramucosal intestinal-type gastric adenocarcinoma. Despite hematologic optimization, chemotherapy, and total gastrectomy, the patient died from severe malnutrition. Early surveillance and multidisciplinary management are essential to improve outcomes in patients with FA.
Keywords: Fanconi. Anemia. Gastric. Adenocarcinoma. Malignancy.
